In 1963 the squadron transitioned from the R6D Liftmaster to the C-130E Hercules (the only R6D squadron to make this transition). Equipped with 10 C-130E's, it was a major tenant at NAS Norfolk VA, operating its own major repair and maintenance facilities. Manned by some 140 officers and 500 enlisted men, it was headquartered in Hangar SP2 in the northwest corner of NAS Norfolk. Its operating schedule now included frequent flights to Puerto Rico, The Azores Islands, Labrador and Newfoundland. Special missions or emergencies have take VR-22 aircraft as far afield as Turkey, Iran and the Congo
In 1965 the squadron was relocated to NAS Moffett Fled, CA to assist in the added burden in the Pacific, created by the Vietnam conflict. It joined long time MATS squadrons VR-7 and VR-8 in this endeavor under the Navy's Naval Air Transport Wing of the Pacific Division of MATS. This squadron had compiled enviable records for flight safety, maintenance and aircraft availability and continued to distinguish itself amongst its Pacific peers. The commitments it made were met and often exceeded, planning it among the top of all MATS/MAC squadrons. Indeed, the squadrons operations were best summed up in their motto - "Omni Tempore Ubiuis" - ANY TIME, ANY WHERE!